Wednesday, February 27, 2008

Antidepressants don't work - in Hull


Researchers from Hull University are claiming that antidepressants only work for patients who are severely depressed.

Whilst Dr Rant is perfectly willing to believe that placebo is just as good as antidepressants for mild to moderate depression, I think we do need to point out a glaring problem with this research. It's from Hull. I mean, have you been to Hull? Fuck, if I lived in Hull I'd be depressed and I don't think antidepressants would help. The 1960s didn't happen in Hull until about 1985.

Here's a suggestion: next time compare the effects on depression of taking placebo against simply moving to somewhere that isn't Hull.

27 comments:

Zarathustra said...

LOL!


That's a bit harsh, Hull isn't nearly as depressing as...oh wait, no, I've never been anwwhere as fucking grim and depressing as Hull.

Am Ang Zhang said...

Have you been to Connecticut? Martha Stuart lives there and Paul Newman has a house there too. They do not even lock their doors. You have private lakes with big Bass stocked for fishing. Oh, I mean some parts of Connecticut of course. Why did this psychologist move to Hull from Connecticut? I did wonder about that and gave a full chronology of various news and research on the topic in my latest blog entry, Groundhog Day and Prozac.

Who said there is a brain drain from Britain, Connecticut to Hull, Armenia, Iraq and then Ireland to Britain and now a Baron.

The Cockroach Catcher

Niall said...

They had a bloke on radio 4 today program from Hull University. He said the same thing as you. Serious depression requires pills but little significant difference in outcomes for more mild cases.

He was also very definitely not from Hull originally.

Hope this is reassuring.

Gareth said...

Dr Rant's facetious comment on a story that has huge implications for the health industry confirms the impression that UK doctors are a bunch of wingeing, self-serving hyprocrits. I say "impression" because many actual doctors are not like this, but the ones that continually put out their views on websites like this and in the media are extraordinarily over-privileged and the public are getting wearied by their bleating. You crammed and got good A-level grades, so? Get over yourselves!

mongoose said...

Zara...

Go a bit further north and you come to Hartlepool. While I did a job in Hartlepool, I stayed in Hull. Good grief!

Dr Rant said...

Fuck off and get a life, Gareth, you humourless, po-faced, freak.

hughev said...

any ssri would not work when John Prescott is your MP. And they must be taken for a long time-until the next election?

Dr. Jane Doe said...

Fucking hell, gareth? Way to wail on the folk with an actual sense of humour and stuff. Are you depressed or something? Maybe you, too, should move from Hull...

Or maybe you should have an enema and get that poker out of your ass once and for all.....

Nursing Student said...

Hull? Nay lad, tha wants to get tha'self to Middlesbrough. THEN you know the meaning of depression!

Well, it's nice to say that these anti-depressants may not work. But can any of the Dr Rant team say they would happilly stand up in court and explain to the coroner based on one piece of research why Mr Jones did not get antidepressants, and why he jumped infront of a train/into a river etc.

I can see the headlines forming now for another media witch hunt.

The two weeks on a trolley team said...

This study has already had a lot of people asking whether they need to be on their meds or not.

Which is a shame, as the conclusions drawn do not reflect what's in the study. This would not have gotten into a better journal as is.

Their modelling is crap, and they have demonstrated very little link between what they are concluding, and what they have actually shown.

Not to pimp a website, but we're having a discussion about this topic on www.boards.ie in the biology+medicine forum which is quite interesting

http://www.boards.ie/vbulletin/showthread.php?t=2055244028

Dr Thunder
www.twoweeksonatrolley.blogspot.com

Tomrat247 said...

Doc Rant,

Hull is indeed very depressing and no place to do a study about the effects of depression but your way way off the mark; everyone knows that Milton Keynes is the most depressing (and scary) place in Britain.

ITS COMPLETELY SYMMETRICAL!!!!!DOESN'T THAT BOTHER ANYONE?

Anonymous said...

fuck off gareth you thick bastard.

Anonymous said...

Gareth - piss off back to your NuLabour bunker you cunt

Am Ang Zhang said...

The researchers were led by someone from Connecticut. No doubt a lot of Ph. D.s (The only Ph. D.s not needing a first degree in the U.K., have you doctors not noticed, so that they can be called DOCTORS!!!) worked with him.The research has nothing to do with the depressed people of Hull. They were all about the undisclosed papers to the F.D.A. across the pond. Have you not noticed that the NICE guideline on Anorexia is from the British Psychological Society? If SSRIs work, no one will want CBT, would they. ????Conflict of interest not declared. Remember the one recommending we eat bread was working for the grain corporation. But business is business.


The Cockroach Catcher

jayann said...

If SSRIs work, no one will want CBT,

quite. (Someone was saying CBT anyway is no better than placebo -- but I couldn't work out what the placebo would be!)

Dr of fuck all said...

You arrogant pricks have some nerve putting your medical degrees up front to validate your personal opinions Mr and Mrs fucking Rank. I have read thru pages of f u c k i n g wh i i n nii n g and w h iii yyyiii n nninnng about how bad your patients are going to suffer because you can't have it all your way yada FooKinG Yada and pull apart all the news and scan for reprints and newsniffing bollox about how little GPs are held in high fucking esteem nowadays ... yet when it comes down to something that seriously disturbs and distresses 20 million of your allegedly precious patients - you take THE FUCKING PISS?
No - YOU take the fucking piss.

And Rhyl is far fucking worse anyhow.

Dr Rant said...

"yet when it comes down to something that seriously disturbs and distresses 20 million of your allegedly precious patients - you take THE FUCKING PISS?"


The humourless and dull try to take comfort in their view that 'humour' is frivolous and pointless.

Clive James says that "humour is common sense dancing". He also pointed out that things don't stop being funny when someone dies just as things don't stop being sad because someone laughs.

Or, translated into Rantese, 'Fuck off you humourless wanker!'.

steveg said...

may I interject here?

Gareth - If you are going to pick holes at someone I suggest you at least run a spell check first - Dr rant (the clue is in the title) may shout and swear but at leasr he can spell "Hypocrites" correctly.

Mongoose - you are nearly there when suggesting the monkey hangers (check it up about Hartlepool's past - they do hang monkeys there! :-)

However, Nursing student wins the prize for me - Middlesborough is by for the worst, it is even alluded to is the Chris rea song "Road to Hell" - check it out you'll find I'm right.

Though as I live in Yorkshire, I have to agree Hull is REALLY REALLY bad....

Cheers Mates

Steve

steveg said...

Bugger!

I spoiled that effort didn't I?

I can spell, I just can't flippin' well type

(Just washed my hands and can't do a thing with them) :-)

Steve

Mr Ian said...

aka Dr of fuck all
"Or, translated into Rantese, 'Fuck off you humourless wanker!'."

On the contrary; your perilous plight to fruitlessly agenda your own opinions and personal needs provides me with endless amusement.

In such belief, you are suggesting it is 'ok' to stand at the patient's bed after passing away and crack some funny at the family like "Oh well if one of you wants to pop off and die now I can do you two for the price of one" just to ease the tension?

Time and place.
Your post was right place, wrong time.

I like the 'common sense dancing' analogy.

mongoose said...

Steve, the way I heard it the monkey committed suicide.

steveg said...

mongoose said...

Steve, the way I heard it the monkey committed suicide.

**************

Well so would I, if I had been detained in Hartlepool as he(?) was..

I still would like to call them Monkeyhangers though... :-)

ForFuckSake said...

"In such belief, you are suggesting it is 'ok' to stand at the patient's bed after passing away and crack some funny at the family like "Oh well if one of you wants to pop off and die now I can do you two for the price of one" just to ease the tension?"

Fuck me, there are some stupid linear thinking cunts on here.

Doing a study on depression using people who live in a total shithole is obviously amusing and ironic. Not to mention it is bound to produce skewed results and be woefully inaccurate. It doesn't hurt anyone to point this out, and it IS funny.
The same brigade who think fatty fat fuckers should be referred to as "horizontally challenged", and in all probability, MRSA positive people to be referred to as "microbiologically different" are the same morons who come on to websites and whinge that someone made a funny and they don't get it.
Making a crack at the bedside of a dead patient in front of his relatives is in no way comparable to making a crack about people who live in a dive participating in a depression study. That you could even see a parallel between the two, quite frankly worries me as you are obviously intelligent enough to use a computer and type things in English. I'm afraid if people that dumb and incapable of lateral thinking are able to masquerade as normal, non cretinous humans not from the Cromagnon era, that they might fool everyone and get into things like politics and government and...oh

Mr Ian said...

"Doing a study on depression using people who live in a total shithole is obviously amusing and ironic."

Probably, but what does this have to do with the recent research? The team were from Hull - the studies were mostly from the annals of the pharmaceutical company.

"Fuck me, there are some stupid linear thinking cunts on here."
The team are from Hull therefore they must be talking about people from Hull?

My apologies, I didn't realise you were so ill-informed.

Dr Pink said...

Interestingly, one of the authors seems to suffer from linear thinking too:

There seems little reason to prescribe anti-depressant medication to any but the most severely depressed patients - Professor Irving Kirsch, University of Hull

Er, no. The study shows that antidepressants DO work in depression. It's just they don't work any better than placebo. But, we don't know if placebos work when the patient knows they are being given placebo.

Only option in reality is usually either do nothing (CBT is very think on the ground) or give antidepressants that work 30-60% of the time.

No brainer at this time.

Gareth said...

Some interesting arguments in favour of homeopathy here. It'd be cheaper and wouldn't put NHS millions into big pharma coffers.

Once upon a time there was a pedant who said "You can not spell" but the living language moved on, the pedant was forgotten by history and "can't" became part of the language...

McCarthy said...

Antidepressants like xanax are the most popular form of depression cure. However, as per recent observations and studies, probabilities are rife that the antidepressants are not that suitable to be administered to patients with low to medium depression. They work best only when they are prescribed to the patients with high depression symptoms.